How Do You Know You’re Not a Man Trapped in a Woman’s Mind?

Questions about whether there’s any issue with responding to “I’m a woman trapped in a man’s body” with “How do you know you’re not a man trapped in a woman’s mind” and how to respond to a meme that says God makes transsexuals so they can share in the act of creation.

* Is there any issue with responding to “I’m a woman trapped in a man’s body” with “How do you know you’re not a man trapped in a woman’s mind?” 

* How should I respond to a meme that says, “God blessed me by making me transsexual for the same reason God made wheat but not bread and fruit but not wine—so that humanity might share in the act of creation.”